Mechanisms Maintaining Mitochondrial DNA Polymorphisms: The Role of Mito-Nuclear Interactions, Sex-Specific Selection, and Genotype-by-Environment Interactions in Drosophila subobscura

Eric, Pavle és Veselinovic, Marija Savic és Patenkovic, Aleksandra és Tanaskovic, Marija és Kenig, Bojan és Eric, Katarina és Indic, Boris és Stanovcic, Stefan és Jelic, Mihailo (2025) Mechanisms Maintaining Mitochondrial DNA Polymorphisms: The Role of Mito-Nuclear Interactions, Sex-Specific Selection, and Genotype-by-Environment Interactions in Drosophila subobscura. INSECTS, 16 (4). ISSN 2075-4450

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Absztrakt (kivonat)

Experimental mito-nuclear introgression lines (MNILs) were established by backcrossing isofemale lines of D. subobscura originating from the same populations. MNILs were subjected to a series of life-history experiments designed to test the fitness of the bearers of different combinations of two main mtDNA haplotypes on their own nuclear background, as well as on the background of the opposite haplotype. By having 11 replicas of the four mito-nuclear combinations, we could test not only the adaptive significance of the differences between the two main haplotypes but also the influence of additional variation present within each of the 11 combinations on fitness. Testing the fitness of individuals of both sexes enabled us to examine if sex-specific selection has a role in maintaining the frequencies of the two mtDNA haplotypes in nature. Conducting the fitness assays on two different temperatures enabled us to test whether different temperatures favor specific mtDNA haplotypes or mito-nuclear genotypes and consequently promote stable sympatric mtDNA variation. The results show weak signature of genotype-by-environment interactions, and no sex-specific selection regarding differences between the two main haplotypes. However, individual models across different life-history components showed these two mechanisms at play in promoting mtDNA variability present in specific mito-nuclear crosses. Our models show that mito-nuclear interactions are, in fact, more important as units of selection.

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Mű tipusa:	Cikk
SWORD Depositor:	Teszt Sword
Felhasználó:	Csaba Horváth
A mű MTMT azonosítója:	MTMT:36125339
Dátum:	08 Máj 2025 10:05
Utolsó módosítás:	08 Máj 2025 10:05
URI:	http://publicatio.uni-sopron.hu/id/eprint/3617

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